I have seen two problems after upgrading to Windows 8 (for 1) and Windows 10 (for 1 and 2):
1. MF toolbox failed with error message "Cannot open the scanner. The Scanner is not acive or in use by another application."
2. Windows FAX and SCAN worked OK even though MF toolbox did not work. Scan failed after USB cable is unplugged and replugged. I needed to restart WIA service before replugging the cable to get around it.
I have reinstalled MF toolbox and driver many times but in vain.
In the end,
1. Problem 1 is solved by adding PATH environmental variable pointing to C:\Windows\twain_32\PrinterModel. Learn it from
2. Problem 2 is solved by installing the patch NetworkUSBScanPatchEN as mentioned in this message chain.